Programmed Cell Death 1-Directed Immunotherapy for Enhancing T-Cell Function
نویسندگان
چکیده
منابع مشابه
Programmed cell death 1-directed immunotherapy for enhancing T-cell function.
T-cell exhaustion is a unique state that appears during many chronic infections and cancer and is characterized by loss of proliferative capacity and effector function. Complex mechanisms are involved in this T-cell dysfunction but an inhibitory receptor, PD-1, has been identified as a major regulator of T-cell exhaustion. Blockade of the PD-1 pathway can reinvigorate exhausted T cells, resulti...
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CD8(+) T cells become exhausted, inducing cell surface protein programmed cell death-1 (PD-1) as chronic virus diseases or tumors progress, but underlying mechanisms of this are unclear. We previously showed that M-CSF is important for developing tolerogenic dendritic cells (DCs) from human CD14(+) monocytes. In this article, we identify M-CSF-derived DCs (M-DCs) after stimulation with IL-10 as...
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The mammalian immune system is a complex network of many cell types and proteins that collectively coordinate a protective response against foreign entities. The immune system can be divided into two broad categories: innate and adaptive immunity. Adaptive immunity, which is primarily mediated by T and B lymphocytes, first arose in jawed vertebrates and has several distinct features from the mo...
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INTRODUCTION A major pathophysiologic mechanism in sepsis is impaired host immunity which results in failure to eradicate invading pathogens and increased susceptibility to secondary infections. Although many immunosuppressive mechanisms exist, increased expression of the inhibitory receptor programmed cell death 1 (PD-1) and its ligand (PD-L1) are thought to play key roles. The newly recognize...
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ژورنال
عنوان ژورنال: Cold Spring Harbor Symposia on Quantitative Biology
سال: 2013
ISSN: 0091-7451,1943-4456
DOI: 10.1101/sqb.2013.78.019869